jcem.endojournals.org...
Studies of nucleosome levels estimated by ELISA and of DNA
fragmentation showed that RV induced apoptosis in both papillary and
follicular thyroid cancer cell lines; these effects were inhibited
by pifithrin-{alpha} and by p53 antisense oligonucleotide
transfection.
Resveratrol induces growth inhibition and apoptosis
in metastatic breast cancer cells via de novo ceramide signaling
www.fasebj.org...
In this study we show that resveratrol has a potent
antiproliferative and proapoptotic effect on MDA-MB-231, a highly
invasive and metastatic cell line from human breast cancer known to
be resistant to several anticancer drugs.
Resveratrol induces cell death in colon cancer cells
by a novel pathway involving lysosomal cathepsin D
carcin.oxfordjournals.org...
In human colorectal cancer cells, the polyphenol resveratrol (RV)
activated the caspase-dependent intrinsic pathway of apoptosis. This
effect was not mediated via estrogen receptors. Pepstatin A, an
inhibitor of lysosomal cathepsin D (CD), not
(2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methylbutane ethyl
ester, an inhibitor of cathepsins B and L, prevented RV cytotoxicity.
Similar protection was attained by small interference RNA-mediated
knockdown of CD protein expression.
Resveratrol induces apoptosis in human esophageal
carcinoma cells
carcin.oxfordjournals.org...
Resveratrol inhibited the growth of esophageal cancer cell line
EC-9706 in a dose-and time-dependent manner. Resveratrol induced
EC-9706 cells to undergo apoptosis with typically apoptotic
characteristics, including morphological changes of chromatin
condensation, chromatin crescent formation, nucleus fragmentation
and apoptotic body formation.
Resveratrol-induced cell death in leukaemia cells
chesterrep.openrepository.com...
Resveratrol, a natural phytoalexin found in grapes and red wine,
displays anti-cancer activities through a variety of mechanisms that
include the induction of cancer cell apoptosis. Although high
concentrations may be needed for the efficacy of resveratrol alone,
the compound shows promise as a potent sensitizer of the apoptotic
effect of other anti-cancer agents, including death ligand TRAIL.
Intracellular heat shock proteins (Hsps) are frequently up-regulated
in cancer cells, conferring resistance to apoptosis. Modulation of
these proteins may overcome the resistance and increase efficacy of
anticancer therapies. In this study, resveratrol caused significant
dose-dependent apoptosis or necrosis in the lymphoid and myeloid
leukaemia cell lines Jurkat and U937 at 50µM and above.
Resveratrol interferes with AKT activity and
triggers apoptosis in human uterine cancer cells
www.ncbi.nlm.nih.gov...
High-dose of resveratrol triggered apoptosis in five out of six
uterine cancer cell lines, as judged from Hoechst nuclear staining
and effector caspase cleavage. In accordance, uterine cancer cell
proliferation was decreased. Resveratrol also reduced cellular
levels of the phosphorylated/active form of anti-apoptotic kinase
AKT.
Retinoic Acid & Retinamide
en.wikipedia.org...
Retinoic acid is the oxidized form of Vitamin A, with only partial
vitamin A function. Retinamide is a synthetic retinoid useful when
retinoic acid treatment is unresponsive.
Retinoic acid receptor beta mediates the
growth-inhibitory effect of retinoic acid by promoting apoptosis in
human breast cancer cells
mcb.asm.org...
Retinoids are known to inhibit the growth of hormone-dependent
but not that of hormone-independent breast cancer cells. We
investigated the involvement of retinoic acid (RA) receptors (RARs)
in the differential growth-inhibitory effects of retinoids and the
underlying mechanism. Our data demonstrate that induction of RAR
beta by RA correlates with the growth-inhibitory effect of retinoids.
The hormone-independent cells acquired RA sensitivity when the RAR
beta expression vector was introduced and expressed in the cells.
N-(4-hydroxyphenyl)retinamide induces apoptosis of
malignant hemopoietic cell lines including those unresponsive to
retinoic acid
www.ncbi.nlm.nih.gov...
In conclusion, our study demonstrates that HPR suppresses
malignant cell growth and induces apoptosis at pharmacologically
relevant doses. The differential responsiveness by a number of cell
lines, especially HL-60R and NB306, to HPR and RA indicates that
these compounds may act through different receptors. The clinical
use of HPR, particularly in retinoic acid-unresponsive acute
promyelocytic leukemia patients, is suggested.
Differential induction of apoptosis by all-trans-retinoic
acid and N-(4-hydroxyphenyl)retinamide in human head and neck squamous
cell carcinoma cell lines
clincancerres.aacrjournals.org...
Retinoids have been shown to act as cytostatic agents against a
variety of tumor cell types, including squamous carcinoma cells.
Recently it was reported that certain retinoids can induce apoptosis
as well. Because we are investigating the potential of retinoids in
chemoprevention and therapy for head and neck premalignant and
malignant lesions, we compared the effects of all-trans-retinoic
acid (ATRA) and N-(4-hydroxyphenyl)retinamide (4HPR) on seven human
head and neck squamous cell carcinoma cell lines (17A, 17B, 22A,
22B, 38, SqCC/Y1, and 1483). Six of the seven cell lines showed
dramatic morphological changes after treatment with 10 micrometer
4HPR, whereas no such changes were induced by 10 micrometer ATRA.
...These results demonstrate that 4HPR causes apoptosis in several
head and neck squamous cell carcinoma cell lines and that it is more
potent in this effect than ATRA.
Rhein
Food: Rhubarb
en.wikipedia.org...
Rhein-induced apoptosis in A-549 Human Lung Cancer
cells
ar.iiarjournals.org...
The Ca2+ chelator BAPTA was added to the cells before rhein
treatment, thus blocking the Ca2+ production and inhibiting rhein-induced
apoptosis in A-549 cells. Our data demonstrate that rhein induces
apoptosis in A-549 cells via a Ca2+-dependent mitochondrial pathway.
Rhein lysinate suppresses the growth of tumor cells
and increases the anti-tumor activity of Taxol in mice
www.ncbi.nlm.nih.gov...
In previous studies, rhein, one of the major bioactive
constituents in the rhizome of rhubarb, inhibited the proliferation
of various human cancer cells. However, because of its water
insolubility, the anti-tumor efficacy of rhein was limited in vivo.
In this study, we observed the anti-tumor activity of rhein lysinate
(the salt of rhein and lysine easily dissolves in water) in vivo and
investigated its mechanism. ...It inhibited tumor growth by both
intragastric and intraperitoneal administrations and improved the
therapeutic effect of Taxol in H22 hepatocellular carcinoma mice. In
conclusion, rhein lysinate offers an anti-tumor activity in vivo and
is hopeful to be a chemotherapeutic drug.
Rhein induces apoptosis in HL-60 cells
www.ncbi.nlm.nih.gov...
Rhein is an anthraquinone compound enriched in the rhizome of
rhubarb, a traditional Chinese medicine herb showing anti-tumor
promotion function. In this study, we first reported that rhein
could induce apoptosis in human promyelocytic leukemia cells
(HL-60), characterized by caspase activation, poly(ADP)ribose
polymerase (PARP) cleavage, and DNA fragmentation. ...Our data
demonstrate that rhein induces apoptosis in HL-60 cells via a ROS-independent
mitochondrial death pathway.
Rhein Inhibits the Growth and Induces the Apoptosis
of Hep G2 Cells
www.ncbi.nlm.nih.gov...
The effects of rhein on the human hepatoblastoma G2 (Hep G2) cell
line were investigated in this study. The results showed that rhein
not only inhibited Hep G2 cell growth but also induced apoptosis and
blocked cell cycle progression in the G1 phase.
Rhein Induced Apoptosis...in SCC-4 Human Tongue
Squamous Cancer Cells
iv.iiarjournals.org...
In this study, it was observed that rhein induced S-phase arrest
through the inhibition of p53, cyclin A and E and it induced
apoptosis through the endoplasmic reticulum stress by the production
of reactive oxygen species (ROS) and Ca2+ release, mitochondrial
dysfunction, and caspase-8, -9 and -3 activation in human tongue
cancer cell line (SCC-4).
Rosemary
en.wikipedia.org...
Rosemary may cut cancer-causing agents (in meats)
www.upi.com...
The addition of rosemary extract to ground beef reduces
cancer-causing agents that can form upon cooking, U.S. researchers
said. Heterocyclic amines are mutagenic compounds that form when
meat and fish are cooked at high temperatures -- especially meats
that are grilled, pan-fried, broiled or barbecued -- and are
categorized as human carcinogens, the researchers said.
Selenium
Foods: Brazil Nuts, Other Nuts, Fish, Wheat Flour, Shell Fish,
Chicken, Turkey and many others.
en.wikipedia.org...
Effects of selenium supplementation for cancer
prevention in patients with carcinoma of the skin
www.ncbi.nlm.nih.gov...
Selenium treatment did not protect against development of basal
or squamous cell carcinomas of the skin. However, results from
secondary end-point analyses support the hypothesis that
supplemental selenium may reduce the incidence of, and mortality
from, carcinomas of several sites. These effects of selenium require
confirmation in an independent trial of appropriate design before
new public health recommendations regarding selenium supplementation
can be made.
Redox-mediated Effects of Selenium on Apoptosis and
Cell Cycle in the LNCaP Human Prostate Cancer
cancerres.aacrjournals.org...
The effects of selenium exposure were studied in LNCaP human
prostate cancer cells, and this same cell line adapted to selenium
over 6 months to compare acute versus chronic effects of sodium
selenite, the latter most closely resembling human clinical trials
on the effects of selenium in cancer prevention and therapy. Our
results demonstrated that oxidative stress was induced by sodium
selenite at high concentrations in both acute and chronic
treatments, but outcomes were different. ...Our results in selenite-adapted
cells suggest that selenium may exert its effects in human prostate
cancer cells by altering intracellular redox state, which
subsequently results in cell cycle block.
Selenium-induced inhibition of angiogenesis in
mammary cancer at chemopreventive levels of intake
www.ncbi.nlm.nih.gov...
The trace element nutrient selenium (Se) has been shown to
possess cancer-preventive activity in both animal models and humans,
but the mechanisms by which this occurs remain to be elucidated.
Because angiogenesis is obligatory for the genesis and growth of
solid cancers, we investigated, in the study presented here, the
hypothesis that Se may exert its cancer-preventive activity, at
least in part, by inhibiting cancer-associated angiogenesis. The
effects of chemopreventive levels of Se on the intra-tumoral
microvessel density and the expression of vascular endothelial
growth factor in 1-methyl-1-nitrosourea-induced rat mammary
carcinomas and on the proliferation and survival and matrix
metalloproteinase activity of human umbilical vein endothelial cells
in vitro were examined.
Skullcap
Source: Chinese herb Scutellaria Baicalensis.
en.wikipedia.org...
This herb has mutliple compounds that have had results together and
apart. Make sure it's the exact species.
Wogonin and fisetin induce apoptosis in human
promyeloleukemic cells
www.ncbi.nlm.nih.gov...
Seven structurally related flavonoids including luteolin,
nobiletin, wogonin, baicalein, apigenin, myricetin and fisetin were
used to study their biological activities on the human leukemia cell
line, HL-60. On MTT assay, wogonin, baicalein, apigenin, myricetin
and fisetin showed obvious cytotoxic effects on HL-60 cells, with
wogonin and fisetin being the most-potent apoptotic inducers among
them.
Antitumor effects of Scutellariae radix and its
components baicalein, baicalin, and wogonin on bladder cancer cell
lines
www.goldjournal.net...(00)00467-2/abstract
All the drugs inhibited cell proliferation in a dose-dependent
manner, but baicalin exhibited the greatest antiproliferative
activity. The concentration of baicalin necessary to obtain 50%
inhibition was 3.4 μg/mL for KU-1, 4.4 μg/mL for EJ-1, and
0.93 μg/mL for MBT-2. For KU-1 and MBT-2, the percentage of
cell survival significantly decreased (P <0.05) at a baicalin
concentration of 1 μg/mL. In an in vivo experiment, antitumor
effects of Scutellariae radix on C3H/HeN mice implanted with MBT-2
were investigated. All the control mice showed a progressive
increase in tumor volume, reaching 2.81 ± 0.18 cm3 on day 20 and
5.36 ± 0.44 cm3 on day 25. However, when Scutellariae radix was
orally administered at a dose of 10 mg per mouse one time daily for
10 days from day 11 to day 20, the tumor volume was 1.99 ± 0.19 cm3
on day 20 and 3.86 ± 0.26 cm3 on day 25, a significant inhibition
of tumor growth (P <0.05).
Induction of apoptosis in prostate cancer cell lines
by a flavonoid, baicalin
www.cancerletters.info...(00)00591-7/abstract
The flavonoid baicalin (baicalein 7-D-β-glucuronate),
isolated from the dried root of Scutellaria baicalensis Georgi
(Huang Qin), is widely used in the traditional Chinese herbal
medicine for its anti-inflammatory, anti-pyretic and
anti-hypersensitivity effects. In the present study, we investigated
the in vitro effects of baicalin on the growth, viability, and
induction of apoptosis in several human prostate cancer cell lines,
including DU145, PC-3, LNCaP and CA-HPV-10. The cell viability after
treating with baicalin for 2–4 days was quantified by a
colorimetric
3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium
(MTS) assay. The results showed that baicalin could inhibit the
proliferation of prostate cancer cells.
Effects of wogonin on inducing apoptosis of human
ovarian cancer A2780 cells
www.ncbi.nlm.nih.gov...
Wogonin can inhibit proliferation and induce apoptosis of A2780
cells within a certain concentration range(50-250 microg/ml).
Anticancer effects of wogonin were associated with the induction of
apoptosis and partly with the suppression of telomerase activity.
Reversal of inflammation-associated dihydrodiol
dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance
in nonsmall cell lung cancer cells by wogonin and chrysin
onlinelibrary.wiley.com...
We also showed that IL-6-induced AKR1C1/1C2 expression and drug
resistance were inhibited by wogonin and chrysin, which are major
flavonoids in Scutellaria baicalensis, a widely used traditional
Chinese and Japanese medicine. In conclusion, this study
demonstrated novel links of pro-inflammatory signals, AKR1C1/1C2
expression and drug resistance in NSCLC.
Anticancer effects of wogonin in both estrogen
receptor-positive and -negative human breast cancer cell lines in
vitro and in nude mice xenografts
onlinelibrary.wiley.com...
Wogonin feeding to mice showed inhibition of tumor growth of T47D
and MDA-MB-231 xenografts by up to 88% without any toxicity after 4
weeks of treatment. As wogonin was effective both in vitro and in
vivo, our novel findings open the possibility of wogonin as an
effective therapeutic and/or chemopreventive agent against both
ER-positive and -negative breast cancers, particularly against the
more aggressive and hormonal therapy-resistant ER-negative types.
Sophora
Source: Genus of shrubs native to every continent except Africa &
North America.
en.wikipedia.org...
Ethanolic extracts of Sophora moorcroftiana seeds
induce apoptosis of human stomach cancer cell line SGC-7901 in vitro
academicjournals.org...
The seeds of Sophora moorcroftiana are used in Chinese
traditional medicine for the treatment of verminosis, infectious
diseases, and anti-inflammation. To investigate the antitumor and
induction of apoptosis activity of Sophora moorcroftiana seeds, the
ethanolic extracts from the seeds was prepared and added into the
culture of human stomach cancer cell line SGC-7901 in vitro. The
proliferation and apoptosis of cells treated with the ethanolic
extracts were assessed by tetrazolium salt reduction (MTT) assay,
fluorescence microscopy, transmission electron microscopy, flow
cytometry and agarose gel electrophoresis of DNA fragmentation. The
results showed that the growth of SGC-7901 cells was strongly
inhibited by the ethanolic extracts at the concentration ranging
between 0.31-5.00 mg/ml, and the apoptosis of treated cells was
induced at the concentration of 1.25, 2.50, and 5.00 mg/ml in vitro.
This suggested that the ethanolic extracts from S. moorcroftiana
seeds contain potent antitumor fraction(s) on human stomach cancer
SGC-7901 cells.
A mannose-binding lectin from Sophora flavescens
induces apoptosis in HeLa cells
www.ncbi.nlm.nih.gov...
The objective of this study was to investigate the anti-tumor
activity of a lectin from Sophora flavescens and explore its
potential apoptotic induction mechanism. ...In conclusion, all
experimental results demonstrated that this lectin seems to be a
potent anti-tumor agent for its cytotoxicity and apoptosis effects
on HeLa cells. Also, bioinformatics analyses showed that this lectin
is speculated to bind a certain mannose-containing receptor on
cancer cell surface thereby initiating downstream caspase cascade.
width="14" height="14">
Sophoranone, extracted from a traditional Chinese
medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells
onlinelibrary.wiley.com...
Screening of various natural products in a search for novel
inducers of apoptosis in human leukemia cells led us to identify the
strong apoptosis-inducing activity in a fraction extracted with
methanol from the roots of Sophora subprostrata Chun et T. Chen. We
purified the compound that induced apoptosis in human leukemia cells
and identified it as sophoranone. Sophoranone inhibited cell growth
and induced apoptosis in various lines of cells from human solid
tumors, with 50% inhibition of growth of human stomach cancer MKN7
cells at 1.2 ± 0.3 μM. The growth-inhibitory and
apoptosis-inducing activities of sophoranone for leukemia U937 cells
were very much stronger than those of other flavonoids, such as
daidzein, genistein and quercetin.
Matrine induced gastric cancer MKN45 cells apoptosis
via increasing pro-apoptotic molecules of Bcl-2 family
www.ncbi.nlm.nih.gov...
Matrine, one of the main active components from the dry roots of
Sophora flavescence, was known to induce apoptosis in a variety of
tumor cells in vitro. However, the molecular mechanism of cell
apoptosis induced by Matrine remains elusive. Here, we investigated
the apoptosis in Matrine-treated human gastric cancer MKN45 cells.
The results showed that Matrine could inhibit cell proliferation and
induce apoptosis in a dose-dependent manner. Further immunoblots
revealed that in Matrine-treated cells, caspase-3, -7 were activated
and the pro-apoptotic molecules Bok, Bak, Bax, Puma, and Bim were
also up-regulated. Our results suggested that Matrine induced
gastric cancer MKN45 cells apoptosis via increasing pro-apoptotic
molecules of Bcl-2 family.
Leachianone A as a potential anti-cancer drug by
induction of apoptosis in human hepatoma HepG2 cells
www.ncbi.nlm.nih.gov...
The Chinese herbal medicine Radix Sophorae is widely applied as
an anti-carcinogenic/ anti-metastatic agent against liver cancer. In
this study, Leachianone A, isolated from Radix Sophorae, possessed a
profound cytotoxic activity against human hepatoma cell line HepG2
in vitro, with an IC(50) value of 3.4microg/ml post-48-h treatment.
Its action mechanism via induction of apoptosis involved both
extrinsic and intrinsic pathways. Its anti-tumor effect was further
demonstrated in vivo by 17-54% reduction of tumor size in
HepG2-bearing nude mice, in which no toxicity to the heart and liver
tissues was observed. In conclusion, this is the first report
describing the isolation of Leachianone A from Radix Sophorae and
the molecular mechanism of its anti-proliferative effect on HepG2
cells.
Tumor-specificity and Apoptosis-inducing Activity of
Stilbenes and Flavonoids
ar.iiarjournals.org...
A total of eleven stilbenes [1-6] and flavonoids [7-11] were
investigated for their tumor-specific cytotoxicity and
apoptosis-inducing activity, using four human tumor cell lines (squamous
cell carcinoma HSC-2, HSC-3, submandibular gland carcinoma HSG and
promyelocytic leukemia HL-60) and three normal human oral cells
(gingival fibroblast HGF, pulp cell HPC, periodontal ligament
fibroblast HPLF). All of the compounds, especially sophorastilbene A
[1], (+)-α-viniferin [2], piceatannol [5], quercetin [9] and
isoliquiritigenin [10], showed higher cytotoxicity against the tumor
cell lines than normal cells, yielding tumor-specific indices of
3.6, 4.7, >3.5, >3.3 and 4.0, respectively. Among the seven
cell lines, HSC-2 and HL-60 cells were the most sensitive to the
cytotoxic action of these compounds. Sophorastilbene A [1],
piceatannol [5], quercetin [9] and isoliquiritigenin [10] induced
internucleosomal DNA fragmentation and activation of caspases -3, -8
and -9 dose-dependently in HL-60 cells. (+)-α-Viniferin [2]
showed similar activity, but only at higher concentrations. All the
compounds failed to induce DNA fragmentation and activated caspases
to much lesser extents in HSC-2 cells. Western blot analysis showed
that sophorastilbene A [1], piceatannol [5] and quercetin [9] did
not induce any consistent changes in the expression of pro-apoptotic
proteins (Bax, Bad) and anti-apoptotic protein (Bcl-2) in HL-60 and
HSC-2 cells. An undetectable expression of Bcl-2 protein in control
and drug-treated HSC-2 cells may explain the relatively higher
sensitivity of this cell line to stilbenes and flavonoids.
Soy: Good or Bad?
There's conflicting data on the effects of Soy on "estrogen
positive" cell lines. Before taking on a Soy regimen, you'll need
to know whether or not your cancer is estogen positive or negative, do
more research, and consult your physician.
From there Soy has multiple compounds shown individually to fight
cancer. It includes compounds such as Daidzein & Genistein, while
Soy fermented with Bacillus Subtilis is the highest known natural
source of Vitamin K2.
Spikemoss
Plant: Selaginella Tamariscina
en.wikipedia.org...
Selaginella tamariscina induces apoptosis via a
caspase-3-mediated mechanism in human promyelocytic leukemia cells
www.ncbi.nlm.nih.gov...
ST-induced apoptosis is accompanied by the activation of
caspase-3 and the specific proteolytic cleavage of PARP.
Concomitantly, ST treatments led to an increase in the proapoptotic
Bax levels, while Bcl-2 expression was decreased. Moreover, this
effect was attenuated by SOD and catalase. These results suggest
that oxidative stress may be involved in the cytotoxicity of ST, and
that ST-induced apoptosis of HL-60 cells is primarily mediated by
the caspase activation pathway.
Effects of Selaginella tamariscina on in vitro tumor
cell growth, p53 expression, G1 arrest and in vivo gastric cell
proliferation
www.ncbi.nlm.nih.gov...
The 1% Selaginella tamariscina feeding caused a significant
reduction (P < 0.05) in the proliferating cell nuclear antigen-(PCNA)
labeling index of the glandular stomach epithelium as compared with
the MNNG-alone group value although 5% Selaginella tamariscina
feeding was only associated with a tendency for decrease. These
results suggest that Selaginella tamariscina could be a candidate
chemopreventive agent against gastric cancer.
Radioprotective effects of the water-soluble part of
Selaginella Tamariscina on thymus and spleen in irradiated mice
en.cnki.com.cn...
Conclusion The water-soluble part of Selaginella tamariscina can
protect mice from rays by inhibiting of apoptosis,adjusting of cell
cycle progression of thymus and spleen cells in irradiated mice.
Stonebreaker
Herb: Phyllanthus Niruri (Chinese Medicinal Herb)
en.wikipedia.org...
Phyllanthus urinaria triggers the apoptosis and
Bcl-2 down-regulation in Lewis lung carcinoma cells
www.ncbi.nlm.nih.gov...
Phyllanthus urinaria (P. urinaria), a widely used herb medicine,
was tested for the anticancer effect in its water extract for the
first time. The water extract of P. urinaria significantly decreased
the number of Lewis lung carcinoma cells in a dose-and
time-dependent manner as determined by MTT assay. However, the water
extract of P. urinaria did not exert any cytotoxic effect on normal
cells such as endothelial cells and liver cells. Result from flow
cytometry revealed a dose-dependent increase of dead cells 24 hours
after treating Lewis lung carcinoma cells with P. urinaria extract.
In-vitro Inhibitory Effect of Phyllanthus Urinaria L
Compound on Proliferation of Human liver Cancer Cell HePG_2 and Its
Apoptosis Induction
en.cnki.com.cn...
Within a certain limit of concentrations,the higher the
concentration and the longer the acting time,the stronger the
inhibition.Co-cultured with 500 μ g/mL Phyllanthus Urinaria L
compound for 72 h,the inhibitory rate reached 93.58 % and IC50 was
240 μ g/mL.Phyllanthus Urinaria L compound at different
concentrations had an certain effect on inducing cell
apoptosis.Conclusion Phyllanthus Urinaria L compound can inhibit the
proliferation of hepatoma cell,and its mechanism may be related with
the induction of hepatoma cell HePG2 apoptosis.
Phyllanthus Amarus Inhibits Cell Growth and Induces
Apoptosis in Daltons Lymphoma Ascites Cells
ict.sagepub.com...
The authors found in an earlier study that Phyllanthus amarus
extract could significantly inhibit the solid and ascites tumor
development in mice induced by Dalton’s lymphoma ascites (DLA)
cells. In the present study, the apoptotic effects of P.amarus
against DLA cells in culture was evaluated. P.amarus produced
significant reduction in cell viability as determined by the MTT
assay.
